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Tuesday, August 18, 2026

Isocyanates- occupational Asthma


  • Work-related asthma is the most common occupational lung disease. There are two categories:

 (1) occupational, or work-related asthma that is caused de novo by work

(2) work-exacerbated asthma, which implies a work-related worsening in the setting of preexisting asthma.

  • Agents That Cause Occupational Asthma

Many agents cause occupational asthma. Two categories of agents can be classified based on molecular weight and differing mechanisms causing disease: 

- High-molecular-weight (HMW) compounds (>5 to 10 kDa)

 - Low-molecular-weight (LMW) compounds



Source- Fishman 6E - Pg 1532

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