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Wednesday, August 19, 2026

A-a gradient

Alveolar arterial Oxygen gradient
A-a=PA02-pa02

PA02=FiO2x (Patm-PH2O) -PaCO2/R

FiO₂: Fraction of inspired oxygen (room air is Atmospheric pressure (typically 760 mm Hg at sea level)

PH2O: Water vapor pressure in the lungs (typically 47 mm Hg at 37°C)

PaCO₂: Arterial partial pressure of carbon dioxide (from an Arterial Blood Gas (ABG) test)

R: Respiratory quotient (normally assumed to be 0.8)

PaO2-arterial partial pressure of oxygen (from an ABG)
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