The most common cause is pleural effusion, but blunting is not synonymous with effusion.
1. Pleural causes
Pleural effusion — most important/common
CHF
Parapneumonic effusion/empyema
Tuberculosis
Malignancy
Cirrhosis/hepatic hydrothorax
Nephrotic syndrome, etc.
Pleural thickening
Previous TB
Empyema
Hemothorax
Pleural malignancy
Asbestos-related disease
Pleural fibrosis/calcification
Post-pleural surgery
2. Extrapleural / pulmonary causes
Lower-lobe consolidation abutting the pleura
Atelectasis of the lower lobe
Peripheral lung mass
Pulmonary infarction
3. Technical/normal variants
Poor inspiration → apparent blunting of both CP angles
Supine film → pleural fluid may layer posteriorly rather than producing the classic meniscus
Obesity/chest wall soft tissue
Pleural recess not fully visualized
