Pathophysiology of early inspiratory crackles in OAD

Premature Airway Opening in Early Inspiration:

During the early phase of inspiration, as negative intrathoracic pressure builds, these collapsed small airways pop open. This sudden opening generates transient sounds—early inspiratory crackles.

Correlation with Disease Severity:

The presence of early inspiratory crackles often correlates with moderate to severe airway obstruction, especially in patients with chronic bronchitis or emphysema.