Hantavirus pulmonary syndrome

Hantavirus Pulmonary Syndrome (HPS) is an acute febrile illness (i.e., temperature greater than 101.0 F [greater than 38.3 C]) with a prodrome consisting of fever, chills, myalgia, headache, and gastrointestinal symptoms,and one or more of the following clinical features: Bilateral diffuse interstitial edema, or

- Clinical diagnosis of acute respiratory distress syndrome (ARDS), or

- Radiographic evidence of noncardiogenic pulmonary edema, or

- An unexplained respiratory illness resulting in death, and includes an autopsy examination demonstrating noncardiogenic pulmonary edema without an identifiable cause, or

- Healthcare record with a diagnosis of hantavirus pulmonary syndrome, or

- Death certificate lists hantavirus pulmonary syndrome as a cause of death or a significant condition contributing to death

Laboratory Criteria For Diagnosis

- Detection of hantavirus-specific immunoglobulin M or rising titers of hantavirus-specific immunoglobulin G, or

- Detection of hantavirus-specific ribonucleic acid in clinical specimens, or

- Detection of hantavirus antigen by immunohistochemistry in lung biopsy or autopsy tissues