kroghs constant--
The single breath method for measuring CO uptake by the lung, which is used world-wide, was introduced by Krogh in 1915.This measurement was termed diffusion constant Krogh's diffusion constant for CO2.KCO2 was determined in respiring muscle tissue at various levels of tissue PCO2.
The carbon monoxide transfer factor (DL,CO) is the product of the two primary measurements during breath-holding, the CO transfer coefficient (KCO) and the alveolar volume (VA). KCO is essentially the rate constant for alveolar CO uptake (Krogh's kCO), and in healthy subjects, increases when VA is reduced by submaximal inflation, or when pulmonary blood flow increases
Krogh constant= DL / VA
unit of DL CO/ VA IS mmol·min−1·kPa−1·L−1.
The single breath method for measuring CO uptake by the lung, which is used world-wide, was introduced by Krogh in 1915.This measurement was termed diffusion constant Krogh's diffusion constant for CO2.KCO2 was determined in respiring muscle tissue at various levels of tissue PCO2.
The carbon monoxide transfer factor (DL,CO) is the product of the two primary measurements during breath-holding, the CO transfer coefficient (KCO) and the alveolar volume (VA). KCO is essentially the rate constant for alveolar CO uptake (Krogh's kCO), and in healthy subjects, increases when VA is reduced by submaximal inflation, or when pulmonary blood flow increases
Krogh constant= DL / VA
unit of DL CO/ VA IS mmol·min−1·kPa−1·L−1.
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