Ctd criteria from Murray and nadal

 Systemic Sclerosis (Scleroderma)

CRITERIA FOR DIAGNOSIS*

Major

Thickening of the skin of the hands

Minor

Sclerodactyly (i.e., the changes of the major criterion but limited to

the fingers)

Digital pitting scars or loss of substance from the finger pad:

depressed areas at tips of fingers or loss of digital pad tissue as a

result of ischemia

Bibasilar pulmonary fibrosis

LUNG MANIFESTATIONS

Interstitial pulmonary fibrosis

Organizing pneumonia

Isolated pulmonary vascular disease

Aspiration pneumonia (secondary to esophageal dysmotility)

Chest wall restriction

*The major or ≥ 2 minor criteria required for diagnosis.

Rheumatoid Arthritis

CRITERIA FOR DIAGNOSIS*

Morning stiffness (lasting at least 1 hr)

Arthritis (soft tissue swelling or fluid) of 3 or more joints (PIP, MCP, 

wrist, elbow, knee, ankle, MTP joints)

Arthritis of hand joints (swelling of at least 1 wrist, MCP, or PIP joint)

Symmetrical arthritis (i.e., simultaneous arthritis of the same joints on 

both sides of the body)

Rheumatoid nodules

Serum rheumatoid factor positivity (at a level such that < 5% of 

normal controls are positive)

Radiographic hand or wrist changes typical of rheumatoid arthritis

LUNG MANIFESTATIONS

Interstitial pulmonary fibrosis

Organizing pneumonia

Obliterative bronchiolitis

Follicular bronchiolitis

Bronchiectasis

Vasculitis

Nodules

Pleural disease

Lymphocytic interstitial pneumonia

Drug induced

*At least 4 criteria for a minimum of 6 weeks.

Systemic Lupus Erythematosus

CRITERIA FOR DIAGNOSIS*

Malar rash

Discoid rash

Photosensitivity skin rash

Oral or nasopharyngeal ulceration

Nonerosive arthritis involving ≥ 2 peripheral joints

Serositis (pleuritis or pericarditis)

Renal disorder (persistent proteinuria or cellular casts)

Neurologic disorder (unexplained seizures or psychosis)

Hematologic disorder (hemolytic anemia, leukopenia, lymphopenia, 

or thrombocytopenia)

Immunologic disorder (positive LE cell, anti-DNA antibody, anti-Sm 

antibody, false-positive syphilis serology)

Elevated antinuclear antibodies

LUNG MANIFESTATIONS

Acute lupus pneumonitis

Interstitial pulmonary fibrosis

Pulmonary vasculitis

Diffuse alveolar hemorrhage

Pulmonary hypertension

Shrinking lung syndrome

Antiphospholipid antibody syndrome

Organizing pneumonia

Pleural disease

*Minimum of 4 criteria required.

Polymyositis with Dermatomyositis

CRITERIA FOR DIAGNOSIS

Symmetrical proximal muscle weakness

Muscle biopsy specimen showing myositis

Elevation of serum skeletal muscle enzymes

Characteristic electromyographic pattern of myositis

Typical rash of dermatomyositis

LUNG MANIFESTATIONS

Interstitial pulmonary fibrosis

Acute pneumonitis (with diffuse alveolar damage)

Organizing pneumonia

Aspiration pneumonia

Pulmonary vasculitis and alveolar hemorrhage

Respiratory muscle weakness

Behçet Syndrome

CRITERIA FOR DIAGNOSIS

Major (required)

Recurrent aphthous ulceration at least 3 times in a 12-mo period

Minor (2 of 4)

Recurrent genital ulceration

Ocular disease

Skin lesions (erythema nodosum, skin ulcers)

Positive pathergy test (a 2-mm erythematous papule or pustule at

the prick site 48 hr after the application of a sterile hypodermic

20- to 22-gauge needle that obliquely penetrated avascular

antecubital skin to a depth of 5 mm)