Indications for Noninvasive Mechanical Ventilation (NIV) in COPD

At least one of the following:

1) Respiratory acidosis (PaCO2 > 6.0 kPa or 45mmHg and arterial pH < 7.35)

2) Severe dyspnea with clinical signs suggestive of respiratory muscle fatigue, increased work of

breathing, or both, such as use of respiratory accessory muscles, paradoxical motion of the

abdomen, or retraction of the intercostal spaces

3) Persistent hypoxemia despite supplemental oxygen therapy

Reference : GOLD 2024