Aminophylline - It is a phosphodiesterase inhibitor used as an adjunct bronchodilator treatment.
Aminophylline predominantly inhibits PDE3 in airway smooth muscles which increases intracellular cyclic AMP leading to bronchodilator effect.
Also has anti-inflammatory properties.
Therapeutic range of 10 -20 mg/l.
Due to narrow therapeutic index and adverse effect profile, along with availability of more effective alternatives, it is now infrequently used in patients with asthma.
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.Dr.Ilangho