Split pleura sign is a Contrast enhanced CT finding in which there is enhancement of the thickened inner visceral pleura and outer parietal pleura separated by pleural fluid
It is seen with Empyema in a setting of bacterial pneumonia
This is due to fibrin deposition in the visceral and parietal pleura as empyema progresses
References:
Kraus G. The Split Pleura Sign. Radiology. 2007;243(1):297-8.
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