Megakaryocyte or platelet clusters, lodged in the peripheral vasculature of the digits, release platelet-derived growth factor (PDGF) and lead to the increased vascularity, permeability, and connective tissue changes that are the hallmark of clubbing.
Release of VEGF and PDGF occurred after platelet impaction and is enhanced by hypoxia. VEGF along with PDGF induces the pathological changes of digital clubbing.
Digital clubbing
From LUNG INDIAMalay Sarkar1, DM Mahesh2, Irappa Madabhavi3
1 Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, India
Release of VEGF and PDGF occurred after platelet impaction and is enhanced by hypoxia. VEGF along with PDGF induces the pathological changes of digital clubbing.
Digital clubbing
From LUNG INDIAMalay Sarkar1, DM Mahesh2, Irappa Madabhavi3
1 Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, India
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.Dr.Ilangho