CLUBBING-PATHOGENESIS PDGF

Megakaryocyte or platelet clusters, lodged in the peripheral vasculature of the digits, release platelet-derived growth factor (PDGF) and lead to the increased vascularity, permeability, and connective tissue changes that are the hallmark of clubbing.

Release of VEGF and PDGF occurred after platelet impaction and is enhanced by hypoxia. VEGF along with PDGF induces the pathological changes of digital clubbing.
Digital clubbing

From LUNG INDIAMalay Sarkar¹, DM Mahesh², Irappa Madabhavi^3
1 Department of Pulmonary Medicine, Indira Gandhi Medical College, Shimla, India

Name reason for Potts spine

Pott disease, or Pott's disease, is a form of tuberculosis that occurs outside the lungs whereby disease is seen in the vertebrae.Tuberculosis can affect several tissues outside the lungs including the spine, a kind of tuberculous arthritis of the intervertebral joints. The disease is named after Percivall Pott (1714–1788), a British surgeon. The lower thoracic and upper lumbar vertebrae are the areas of the spine most often affected. The formal name for the disease is tuberculous spondylitis