American Heart Association Recommendations for Duration of Secondary Prophylaxisa
Rheumatic fever without carditis
DURATION OF PROPHYLAXIS
For 5 years after the last attack or 21 years of age (whichever is longer)
Rheumatic fever with carditis but no residual valvular disease
For 10 years after the last attack, or 21 years of age (whichever is longer)
Rheumatic fever with persistent valvular disease, evident clinically or on echocardiography
For 10 years after the last attack, or 40 years of age (whichever is longer); sometimes lifelong prophylaxis